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Updated: Jun 7, 2025

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
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単分子状態は,転写因子結合と遺伝子発現を結びつける

Benjamin R Doughty1, Michaela M Hinks2, Julia M Schaepe2

  • 1Genetics Department, Stanford University, Stanford, CA, USA.

Nature
|November 20, 2024
PubMed
まとめ

増強剤に結合する転写因子 (TF) は遺伝子発現に影響する. この研究では,TF活性化ドメインがコファクターを勧誘して核細胞を不安定化させ,TF結合協同性を強化し,遺伝子発現のダイナミクスを予測する方法を明らかにした.

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