乳腺の正常な組織には,稀な数のアヌプロイド上皮細胞がある

Yiyun Lin^1,2, Junke Wang^1,2, Kaile Wang¹

¹Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature

|November 20, 2024

まとめ

健康な女性は乳腺組織に希少な形状の皮質細胞を持ちますこれらの細胞は乳がんに多く見られクローン拡張とコピー数の変化を示し年齢とともに増加します

科学分野:

腫瘍学
遺伝学
細胞生物学

背景:

アヌプロイド上皮細胞は乳がんに多く見られます.
正常な乳腺組織における状細胞の存在と特徴は,ほとんど特徴づけられていない.

研究の目的:

乳腺の健康な組織にアヌプロイド上皮細胞の存在,特徴,および影響を調査する.

主な方法:

49人の健康な女性の83, 206個の上皮細胞の複製数の変化をプロファイルするために単細胞DNA配列を解析した.
19人の女性から採取したサンプルで,単細胞DNAとトランスポゼアクセシブルクロマチンの配列解析 (scATAC-seq) を実施した.

主要な成果:

すべての女性は希少なアヌプロイド上皮細胞 (中位数3. 19%) を抱え,その流行率は年齢とともに増加した.
これらのアヌプロイド細胞の有意な割合 (中位数82. 22%) は,入侵性乳がんに見られるようなクローン拡張とコピー数変化を示した (例えば,1qの増加,10q,16q,22qの減少).
アヌプロイド細胞は主に光上皮質の系統と関連しており,明らかに組織病理学的異常のない管状および葉状の構造に位置していた.

結論:

健康な乳腺組織には,クローナルの膨張を経験する希少なアヌプロイド上皮細胞が含まれています.
これらの発見は,正常な乳がん組織内で乳がんの発症の予兆となる可能性があることを示唆しています.

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