孤立した村の社会的ネットワークにおける腸内微生物群の株の共有
Francesco Beghini1, Jackson Pullman1,2, Marcus Alexander1
1Yale Institute for Network Science, Yale University, New Haven, CT, USA.
Nature
|November 20, 2024
まとめ
ヒトのソーシャルネットワークは 親族を超えて 微生物の共有を通じて 腸内微生物を形作ります 社会的に中心的な個人は より多様な腸内細菌を持ち より広いコミュニティとのつながりを反映しています
科学分野:
- 微生物学
- 社会流行病学
- ネットワーク科学
背景:
- 微生物の交換のための環境を作り出します
- 腸内微生物の組成は 社会や環境要因に 影響を受けます
研究 の 目的:
- 社会的ネットワーク構造と腸内微生物の組成の関係を調査する.
- 異なる関係タイプとネットワークの度合いを越えた 微生物の共有を調査する
主な方法:
- 18の村で1787人の成人を対象に ソーシャルネットワークのマッピングと 微生物群のシーケンシングを行いました
- 種レベルと株レベルでの微生物データの分析
- 2年間にわたる301人の微生物群の縦断分析
主要な成果:
- 非家族関係を含む様々な社会的つながりで 微生物の共有が観察されました
- ストレスの共有は2度目の社会的つながりにも広がり,より広範なネットワークの影響力を強調しました.
- 社会的に中心的な個人は 村の住民とより大きな微生物の類似性を示しました
- 接続された個体は,接続されていない個体と比較して,時間の経過とともに株の共有の収束が増加したことを示しました.
結論:
- ソーシャルネットワークは腸内微生物群を構成し 微生物の多様性と組成に影響を与えます
- 家庭や家族を超えた 社会的つながりは 微生物の重要な交換を促進します
- 社会的ネットワークは 微生物群の生物学とその現象的影響を 形作る生態学的ニッチとして機能します
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