関連する実験動画

Updated: Jun 6, 2025

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
12:14

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

Published on: June 2, 2022

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ACSL4と多不飽和脂質は,転移性エクストラバゼーションとコロニゼーションをサポートする

Yuqi Wang1, Mangze Hu2, Jian Cao3

  • 1Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China; Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, China.

Cell
|November 26, 2024
PubMed
まとめ

癌細胞は脂質の含有量を変化させ,フェロプトーシスへの感受性を高めることで広がります. ACSL4やECH1のような脂質代謝酵素をターゲットにすることで,転移を抑制し,新しい治療戦略を提供することができます.

キーワード:
ACSL4 についてECH1 について癌の転移エクストラバゼーションフェロプトーシスへの感受性in vivo CRISPRスクリーニング脂質代謝転移性コロニー化卵巣がんポリ不飽和脂質

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