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Updated: Jun 6, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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阻害と劣化を組み合わせた二重ターゲットと二重メカニズム設計戦略

Yongbo Liu1, Xiuyun Sun2, Qianlong Liu1

  • 1MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing 100084, China.

Journal of the American Chemical Society
|December 2, 2024
PubMed
まとめ

新しいバイ機能分子であるYB-3-17は同時にmTORを阻害し,GSPT1を退廃させ,結晶芽細胞腫に対する有望な精密療法を提供している. このアプローチは耐性を克服し,臨床前モデルの有効性を高めます.

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