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Updated: Jun 5, 2025

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著者 訂正:APOE4は,オリゴデンドロサイトにおけるコレステロールの調節障害を介してミエリン化を阻害する

Joel W Blanchard1,2,3, Leyla Anne Akay1,2,4, Jose Davila-Velderrain4,5

  • 1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nature
|December 5, 2024
PubMed
まとめ

No abstract available in PubMed .

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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