コメンスアル宿主特異性のための保存された細菌の遺伝的基礎
Karina Gutiérrez-García1, Kevin Aumiller1,2, Ren Dodge1
1Biosphere Sciences and Engineering Division, Carnegie Institution for Science, Baltimore, MD, USA.
まとめ
ラクチプランティバシルス・プランタラムは 果物ハエの腸に固着する特定のアデシンを用いて 安定した共生関係を確立します この宿主特有の認識は,ドロソフィラ・メラノガスターの腸内ニッチでの細菌のコロニー化と生存の鍵です.
科学分野:
- 微生物学
- 昆虫 生物学
- 共生関係
背景:
- 動物の腸内細菌は 宿主の健康を向上させます
- バクテリアの共生体は 特定の腸内ニッチで 定着して成長しなければなりません
- アデシンはバクテリアの結合を媒介しますが,持続的な感染にはしばしば追加のメカニズムが必要です.
研究 の 目的:
- ラクチプランティバシルス・プランタラムが ドロソフィラ・メラノガスターの腸を 植民する方法を調査する
- Lactiplantibacillus plantarumがニッチの認識と安定した確立のために使用するメカニズムを特定する.
主な方法:
- 生きているドロソフィラ・メラノガスターの腸内の個々の共生細菌の画像です
- バクテリアの粘着と植民に関与する遺伝要素の分析
主要な成果:
- Lactiplantibacillus plantarumは フルーツフライの前腸を 独特の物理的なニッチとして特定しています
- コロニゼーション・アイランドによってコードされた宿主特有のアデシンは,L. plantarumの安定した確立を可能にします.
- 島内のアデシン結合領域と分泌システムは,関連する細菌にわたって保存されています.
結論:
- Lactiplantibacillus plantarumは,ドロソフィラ・メラノガスターの前腸の標的型コロニー化のために宿主固有のアデシンを利用する.
- 保存された植民島は 昆虫の腸内における 安定した共生細菌の確立を促進します
- この研究は,モデル生物における宿主-微生物の相互作用の基礎にある特定の分子機構を明らかにする.
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