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Updated: Jun 5, 2025

Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
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Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells

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CRISPR-Cas12aを用いたDNA情報保存におけるランダムな浄化

Hongyu Shen1, Zhi Weng1, Haipei Zhao1

  • 1School of Biomedical Engineering, The International Peace Maternity and Child Health Hospital, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|December 10, 2024
PubMed
まとめ

この研究では,CRISPR-Cas12a (RSDISC) を使用したDNAデータストレージのランダム化が導入されています. この方法はDNAファイルを安全に消去し,高い効率を達成し,安全なデータ管理を可能にします.

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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