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Updated: Jun 5, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

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腸炎を治療するための病原体特異的認識と根絶のための超分子スイッチング対応クオラムセンシングトラップ

Xiaojie Wu1, Qinggele Borjihan2, Yueying Su1

  • 1College of Chemistry and Chemical Engineering, Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, 235 Daxue West Road, Hohhot 010021, P. R. China.

Journal of the American Chemical Society
|December 12, 2024
PubMed
まとめ

この研究は,腸内細菌感染と戦うための新しい超分子クオラムセンシング (QS) 罠を導入しています. この革新的なアプローチは 抗生物質耐性や有益な腸内細菌を 破壊することなく 選択的に病原体を排除します

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Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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