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Updated: Jun 5, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

204

栄養素主導のヒストンコードは,CD8+ T細胞の運命を決定する

Shixin Ma1, Michael S Dahabieh2, Thomas H Mann1

  • 1NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.

Science (New York, N.Y.)
|December 12, 2024
PubMed
まとめ

枯渇したT細胞 (TEX) は栄養分代謝を再プログラムし,アセテートからシトラートに切り替えます. この代謝シフトはヒストンのアセチル化を変化させ,T細胞の枯渇と抗腫瘍免疫に影響を与え,新たな治療標的を提示する.

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