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Updated: Jun 5, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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トランポゾンエクソニゼーションによるヒトインターフェロン信号の調節

Giulia Irene Maria Pasquesi1, Holly Allen2, Atma Ivancevic2

  • 1BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; Crnic Institute Boulder Branch, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.

Cell
|December 13, 2024
PubMed
まとめ

移植可能な要素は,代替スプライシングを通じてヒトの免疫信号を調節する. I型インターフェロン受容体 (IFNAR2) のトランポゾン由来変種は,SARS-CoV-2を含む免疫反応を抑制する偽薬として作用する.

キーワード:
代替スプライシング生まれつきの免疫適用可能な要素タイプI IFN

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