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Updated: Jun 4, 2025

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
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コチレノールと1,2-ジオールの対照性グリコシレーション

Dylan W Snelson1,2, Stephen I Ting1, Ryan A Shenvi1,2

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|December 17, 2024
PubMed
まとめ

研究者は,割れる砂糖結合剤を用いた新しいコントラステル・グリコシレーション法を開発した. この効率的な技術により,コチレニンE,J,ISIR-050のような複雑なテルペングリコシドの合成が可能である.

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Wilhelm Rudolph Fittig discovered the pinacol coupling reaction in 1859. It is a radical dimerization reaction and involves the reductive coupling of aldehydes or ketones in the presence of hydrocarbon solvent to yield vicinal diols.
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