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YTHDF2は,B細胞悪性腫瘍におけるATP合成と免疫回避を促進する

Zhenhua Chen1, Chengwu Zeng2, Lu Yang1

  • 1Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Center for RNA Biology and Therapeutics, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.

Cell
|December 18, 2024
PubMed
まとめ

YTHDF2タンパク質は,ATPの合成を促進し,免疫回避を促進することによって,B細胞の悪性腫瘍を駆動します. YTHDF2を標的とした治療は,B細胞がんにおけるキメリック抗原受容体 (CAR) - T細胞治療の有効性を改善する可能性がある.

キーワード:
ATPの生産B細胞の悪性腫瘍CAR-T についてCD19 についてMHC-II についてYTHDF2 についてm ((5) C についてm ((6) A についてメタボリズム

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