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Updated: Jun 4, 2025

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リトコリック酸は,TULP3を結合してシルトゥインとAMPKを活性化させ,老化を遅らせます

Qi Qu1, Yan Chen1, Yu Wang1

  • 1State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.

Nature
|December 18, 2024
PubMed
まとめ

リトコリック酸 (LCA) は,真空のH+-ATPase (v-ATPase) を抑制するシルトゥインの活性を増強することによって,AMP活性化タンパク質キナーゼ (AMPK) を活性化します. TUB型タンパク質3 (TULP3) を含むこの経路は,老化を遅らせるようなカロリー制限の利点を模倣します.

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