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Updated: Jun 4, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

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人工知能を用いたウェアラブルからのデジタルフェノタイプ化は,精神疾患を特徴づけ,遺伝的関連性を特定する

Jason J Liu1, Beatrice Borsari1, Yunyang Li2

  • 1Program in Computational Biology and Biomedical Informatics, Yale University, New Haven, CT 06511, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

Cell
|December 20, 2024
PubMed
まとめ

ウェアラブルなセンサーは 詳細な行動を記録し 青少年における精神疾患を より正確に特定できるようにします このアプローチは遺伝学的研究も強化し 精神疾患との新しい遺伝子関連性を明らかにします

キーワード:
AI についてGWAS について脳についてディープラーニングデジタルフェノタイピング遺伝学ゲノム学個人的な健康精神科ウェアラブル・バイオセンサ

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A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis04:19

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Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
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Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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