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Updated: Jun 4, 2025

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
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G3BP1/2-ターゲティングPROTACは,がん治療としてストレス粒子を依存するATF4の移行を妨げる

Ting Dong1,2, Fabao Zhao3, Mengmeng Wang2

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2A Nanwei Road, Xicheng District, Beijing 100050, China.

Journal of the American Chemical Society
|December 23, 2024
PubMed
まとめ

ストレス粒子を標的とする新しい化合物は,生存因子ATF4の繊維芽細胞から腫瘍細胞への移転を阻害することによって,がんの成長を抑制する. この発見により 癌の治療に新たな戦略が生まれます

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