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Updated: Jun 4, 2025

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
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Published on: April 18, 2025

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FBP1は老朽化したMASH肝細胞からの肝がんの進化を制御する

Li Gu1,2,3, Yahui Zhu4,5, Shuvro P Nandi6,7,8

  • 1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA. ligu@scu.edu.cn.

Nature
|January 1, 2025
PubMed
まとめ

メタボリック機能障害に関連するステアトヘパチス (MASH) は肝がん (HCC) を引き起こす可能性があります. 研究者らは,フルークトーゼ-1,6-二酸化塩素1 (FBP1) の減少が,細胞増殖とDNA変異を促進することによって,HCCの進行を可能にすることを発見しました.

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