関連する実験動画

Updated: Jun 4, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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Mus GPR4とXenopus GPR4による陽子検出の進化的研究と構造的基礎

Xin Wen1, Pan Shang2, Haidi Chen3

  • 1Key Laboratory Experimental Teratology of the Ministry of Education, New Cornerstone Science Laboratory, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China; NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Advanced Medical Research Institute, Shandong University, Jinan, China.

Cell
|January 3, 2025
PubMed
まとめ

この研究は,Gタンパク質結合受容体4 (GPR4) が動物におけるpHをどのように感知するかを明らかにしています. 構造分析により 物理的適応に不可欠な 陽子検出の 共通で独特なメカニズムが発見されました

キーワード:
GPCR についてGPR4 についてクリオ・エム進化についてプロトンセンシング

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