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関連する概念動画

Knee Joint01:23

Knee Joint

1.5K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.5K
Ankle Joint01:10

Ankle Joint

1.4K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

3.3K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
3.3K
Functional Classification of Joints01:09

Functional Classification of Joints

3.8K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
3.8K
Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K

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関連する実験動画

Updated: Jun 4, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

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骨関節炎

Margreet Kloppenburg1, Mosedi Namane2, Flavia Cicuttini3

  • 1Department of Rheumatology, Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.

Lancet (London, England)
|January 4, 2025
PubMed
まとめ
この要約は機械生成です。

骨関節炎 の 原因 に つい て の 理解 が 進歩 し て いる に も かかわら ず,骨関節炎 の 治療 に は 課題 が あり ます. 症状と構造的損傷に対処するために新しい治療法が必要であり,炎症を標的とする治療法が有望である.

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Synovial Fluid Analysis to Identify Osteoarthritis
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Synovial Fluid Analysis to Identify Osteoarthritis

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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

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関連する実験動画

Last Updated: Jun 4, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

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Synovial Fluid Analysis to Identify Osteoarthritis
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Synovial Fluid Analysis to Identify Osteoarthritis

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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

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科学分野:

  • リウマトロジと骨格動脈の健康
  • 遺伝学と微生物群の研究
  • 痛みの管理と治療法

背景:

  • 骨関節炎 (OA) は高齢化と肥満によって引き起こされる 世界的な健康問題です
  • エチオロジーの理解は進化し,遺伝学,微生物群,痛みのメカニズムも含まれています.
  • 現在の治療はしばしば症状の緩和に集中し,病気を修正する選択肢は限られています.

研究 の 目的:

  • 骨格関節炎の病因と管理の課題に関する現在の理解をレビューする.
  • 症状と構造的進行の両方を対象とした新しい治療法の必要性を強調する.
  • 抗炎症療法などの新たな治療戦略を探求する.

主な方法:

  • 骨関節炎の研究における最近の進歩に関する文献レビュー
  • 現在の治療効果と限界の分析
  • 新しい治療目標とアプローチに関する証拠の統合

主要な成果:

  • エチオロジカルな知識が向上したにもかかわらず,新しいOA治療法は依然として稀です.
  • 運動や減量といった 既知の治療法の有効性は 再評価されています
  • 炎症をターゲットにすることが有望です 特に手関節炎の場合です

結論:

  • 骨関節炎の効果的な治療には 患者の要因を考慮した 個別的なアプローチが必要です
  • 疾患変形性関節炎薬 (DMOADs) の開発には 研究を継続することが不可欠です
  • 炎症を標的とした治療は 結腸炎の治療に 有望な手段です