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関連する概念動画

The Blood-brain Barrier00:49

The Blood-brain Barrier

53.7K
Overview
53.7K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

5.6K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
5.6K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

67.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
67.0K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.4K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

6.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
6.5K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

7.5K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
7.5K

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関連する実験動画

Updated: Feb 19, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

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血脳障壁:副腎皮質機能による内生的な調節.

J B Long, J W Holaday

    Science (New York, N.Y.)
    |March 29, 1985
    PubMed
    まとめ
    この要約は機械生成です。

    血脳障壁 (Blood-brain barrier) は,血液と脳との関わりを阻害している.

    さらに関連する動画

    Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport
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    Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

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    Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
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    Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

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    関連する実験動画

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    Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
    04:33

    Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

    Published on: March 12, 2019

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    Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport
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    Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

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    Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
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    科学分野:

    • 神経科学は神経科学である.
    • エンドクリノロジー エンドクリノロジー
    • 生理学 生理学とは

    背景:

    • 血脳障壁 (BBB) は,血流と脳との間の分子輸送を調節する重要なインターフェースです.
    • BBBの浸透性を理解することは,神経学的疾患の診断と治療に不可欠です.

    研究 の 目的:

    • 血脳障壁の浸透性に対する下垂体副腎軸の影響を調査する.
    • 副腎ホルモンが,マクロ分子がBBBを横切る経路を調節するかどうかを判断する.

    主な方法:

    • ネズミは腎上腺切除術,腎上腺脱骨術,または偽手術を受けた.
    • ヨウ素-125ラベルを貼った牛の血清アルブミンは,BBBの透過性を評価するために使用されました.
    • コルチコステロン置換療法は,腎上腺切除されたラットに投与された.

    主要な成果:

    • アドレナレクトミーは,標識された牛の血清アルブミンに対するBBBの透過性を有意に増加させた.
    • アドレナルのデメデュレーションは,BBBの浸透性に影響しませんでした.
    • コルチコステロン置換は,腎上腺切除術によって引き起こされた浸透性の増加を逆転させた.

    結論:

    • pituitary-adrenal axis,特にコルチコステロンなどの副腎ホルモンは,BBBの透過性を調節する役割を果たします.
    • これらの発見は,脳マイクロ血管の整合性のホルモン調節を示唆しています.
    • BBBのマクロ分子への浸透性は,内分泌系によって生理学的に影響を受けます.