関連する実験動画

Updated: Jun 3, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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メタボトロピックGABAB受容体のGタンパク質結合による活性化

Moon Young Yang1, Soo-Kyung Kim1, William A Goddard1

  • 1Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, United States.

Journal of the American Chemical Society
|January 6, 2025
PubMed
まとめ

Gタンパク質結合は,アゴニストだけでなく,メタボトロピックGABA-B受容体 (GABABR) の活性化を誘導する. このGタンパク質 (GP) 相互作用は,GPCRシグナル伝達と薬剤開発の理解に不可欠な重要な形状変化を誘導する.

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