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Updated: Jun 2, 2025

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ヒト副甲状腺ホルモン1型受容体の活性化プロセスを決定する

Yue Zhang1,2, Qingchuan Zheng3, Arieh Warshel4

  • 1School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130012, China.

Journal of the American Chemical Society
|January 13, 2025
PubMed
まとめ

パラチロイドホルモン1型受容体 (PTH1R) の活性化における重要な分子イベントを計算シミュレーションで明らかにし,Gsタンパク質の結合とグアノシン二酸化物 (GDP) の放出を含む. この研究は,活性化エネルギーバリアを明らかにし,PTH1R機能のための重要な残留物を特定します.

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