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Updated: Jun 2, 2025

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
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定量プロテオミクスは,プロフィリン-1を偽ウリジン結合タンパク質として識別する.

Songbo Wei1, Xiaoxia Dai1, Jun Yuan1

  • 1Department of Chemistry, University of California, Riverside, California 92521-0403, United States.

Journal of the American Chemical Society
|January 15, 2025
PubMed
まとめ

プロフィリン-1 (PFN1) は,偽ウリジン (Ψ) を含むRNAに直接結合し, Ψ リーダータンパク質としての役割を明らかにする. この相互作用はmRNAの安定性と翻訳,特にTPI1遺伝子の制御に不可欠です.

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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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