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Updated: Jun 2, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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核選択性アロマティック置換のためのエンジニアリングされた酵素

Thomas M Lister1,2, George W Roberts1,2, Euan J Hossack1,2

  • 1Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.

Nature
|January 15, 2025
PubMed
まとめ

研究者は,ステレオセレクティブの核性芳香置換 (SNAr) 反応のための生物触媒SNAr1.3を開発した. このエンジニアリングされた酵素は 温和な条件下で効率的で選択的なC-CとC-X結合形成を可能にし 医薬品と農薬のグリーン化学を推進します

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In an electrophilic aromatic substitution reaction, an electrophile substitutes for a hydrogen of an aromatic compound.
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