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Updated: Jun 2, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Published on: April 16, 2019

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GZMK発現するCD8+ T細胞は,再発性呼吸道炎症を促進する

Feng Lan1,2,3, Jizhou Li4,5, Wenxuan Miao3,6

  • 1Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Nature
|January 15, 2025
PubMed
まとめ

Granzyme K (GZMK) を発現する持続的なCD8+T細胞は慢性呼吸道炎症と疾患の再発を誘発する. ネズミのGZMKを阻害することで病理が軽減され,GZMKが炎症性疾患の治療標的であることを示唆した.

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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