関連する実験動画

Updated: Jun 1, 2025

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

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肺動脈高血圧の潜在的治療標的としてのインテグリンα5β1の探索:包括的な多センター前臨床試験からの洞察

Sarah-Eve Lemay1, Mónica S Montesinos2, Yann Grobs1

  • 1Pulmonary Hypertension Research Group, Québec Heart and Lung Institute Research Center, Quebec City, QC, Canada (S.-E.L., Y.G., T.Y., T.S., M.M., C.R., M.S., S.B.-B., A.B., C.T., A.P., R.E.K., S.M., K.Y., F.P., S.P., O.B., S.B.).

Circulation
|January 20, 2025
PubMed
まとめ

インテグリンα5β1を標的とした治療は,肺動脈高血圧 (PAH) の有望な新しい治療法です. この分子を抑制すると,血管の改造が効果的に減り,臨床前PAHモデルでは心臓の機能が改善されます.

キーワード:
細胞外マトリックス心臓の心室肺高血圧インテグリンモデル 動物血管の改造

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