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Updated: May 31, 2025

Recombineering Homologous Recombination Constructs in Drosophila
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Recombineering Homologous Recombination Constructs in Drosophila

Published on: July 13, 2013

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完全なヒト再結合マップ

Gunnar Palsson1, Marteinn T Hardarson1,2, Hakon Jonsson1

  • 1deCODE genetics/Amgen Inc., Reykjavik, Iceland.

Nature
|January 22, 2025
PubMed
まとめ

現在の人間の再結合マップには,非交差 (NCO) イベントが含まれており,メオシスの性別の違いが明らかになっています. NCOのこの新しい理解は,集団の歴史,自然選択,そして新しい変異の研究に影響を与えます.

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Subcloning Plus Insertion SPI - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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