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Updated: May 29, 2025

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
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Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

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異体化 ヒストン H4 の 半合成 は,染色体 の 頑丈 さ と 分子 の 老化 に 対する 脆弱 さ を 明らか に し ます

Tianze Zhang1, Luis F Guerra1, Yana Berlina2

  • 1Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

Journal of the American Chemical Society
|February 3, 2025
PubMed
まとめ

タンパク質の老化により,アスパルチン酸 (Asp) がアイソアスパルチン酸 (isoAsp) を形成する. 24位 (H4isoD24) にあるヒストンH4を研究した. H4isoD24はヒストンのメチル化に影響するが,クロマチンの圧縮や再構成には影響しない.

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