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Updated: May 29, 2025

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SKI複合体の損失は9p21.3-削除またはMSI-H癌をPELOに依存させる

Patricia C Borck1, Isabella Boyle1, Kristina Jankovic2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature
|February 5, 2025
PubMed
まとめ

PELOは9p21.3の欠損またはマイクロサテライト不安定性高い (MSI-H) 状態のがんにおける新たな合成致死標的として特定されました. PELOをターゲットにすることで これらの特定の癌のサブタイプに対する 有望な治療戦略が提供されます

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