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Updated: May 29, 2025

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
06:02

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

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RUNX2は,アルベオラから病理性フィブロブラストへの移行を通じて,線維症を促進する

Yinshan Fang1, Sanny S W Chung1, Le Xu2

  • 1Columbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Nature
|February 5, 2025
PubMed
まとめ

研究者は,肺線維症における病理性線維細胞の主要な源として,SCUBE2+アルベオラ線維細胞を含むLEPR+細胞を特定した. これらの細胞にRUNX2を標的にすることで 線維症が軽減され,治療戦略の可能性がある.

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Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition

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