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Updated: Jun 13, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

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GUK1の活性化は,肺がんにおける代謝障害である

Jaime L Schneider1, Kiran Kurmi2, Yutong Dai3

  • 1Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA.

Cell
|February 7, 2025
PubMed
まとめ

肺がんにおけるアナプラスティックリンパ腫キナーゼ (ALK) 信号は,グアニラートキナーゼ1 (GUK1) のリン酸化を誘導し,グアノシン二酸化物 (GDP) の合成を増加させます. GUK1をターゲットにすることで,腫瘍遺伝子の肺がんに対する新しい治療戦略が提供される可能性があります.

キーワード:
ALK についてGDP (国内総生産)GUK1 についてラス信号アナプラスティックリンパ腫キナーゼ癌の代謝ガニラートキナーゼ1肺がん非小細胞肺がんタイロシンキナーゼ阻害剤

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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure09:38

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