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Updated: May 28, 2025

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
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Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

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UM171は,CoRESTコアプレッサーを分解する非対称CRL3-HDAC1/2アセンブリを接着する

Megan J R Yeo1,2, Olivia Zhang1,2, Xiaowen Xie3,4

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature
|February 12, 2025
PubMed
まとめ

UM171は,KBTBD4をHDAC1/ 2に結合させ,コアプレッサーの分解を促進し,血液形成幹細胞の自己再生を促進する分子接着剤として作用する. これは,E3リガゼ複合体を標的とする小分子分解剤の新しいメカニズムを示しています.

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