アナボリックアンドロゲンステロイド使用者の心血管疾患
Josefine Windfeld-Mathiasen1,2, Ida M Heerfordt1, Kim Peder Dalhoff1,2
1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark (J.W.-M., I.M.H., K.P.D., J.T.A., M.A.A., K.S.J., H.H.).
Circulation
|February 13, 2025
まとめ
アナボリックアンドロゲンステロイド (AAS) の使用は,心臓発作や心不全を含む心血管疾患のリスクを大幅に高めます. この大規模な研究は,AAS使用者のリスクが一般の人々と比較して大幅に増加していることを確認しています.
科学分野:
- 心臓病科
- 内分泌学
- 公衆衛生
背景:
- アナボリック・アンドロゲン・ステロイド (AAS) の使用は死亡率の増加と関連しており,心臓血管疾患は死亡の一部に関与している.
- AAS使用者に対する心臓血管の健康への影響は十分に研究されていない.
- この研究は,AASを使用する男性における心血管疾患の発生率を一般の人々と比較したものです.
研究 の 目的:
- 男性AAS使用者の心血管疾患の発生率を定量化するために.
- AAS使用者における心血管疾患の発生率を,一致した一般集団と比較する.
- AASの使用に関連する特定の心血管リスクを特定する.
主な方法:
- デンマークで (2006年〜2018年) 制裁を受けた男性AAS使用者のコホートが確立されました.
- 50: 1の年齢と性別を合わせた対照群をデンマークの全人口から選択した.
- 全国のレジスタリでは,心血管疾患 (例えば,心筋梗塞,心筋病) およびその他の健康データを2023年6月まで追跡した.
主要な成果:
- AAS使用者 (n=1189) は,11年間の追跡期間中,対照群 (n=59, 450) よりも心血管疾患の発生率が著しく高かった.
- AASの使用は,急性心筋梗塞 (aHR 3. 00),再血管化処置 (aHR 2. 95),静脈血栓塞栓症 (aHR 2. 42),不律性 (aHR 2. 26),心筋病 (aHR 8. 90),心不全 (aHR 3. 63) のリスク増加と関連していました.
- AAS使用者における不全性脳卒中および心停止の発生率に関する報告は,限られたデータから除外された.
結論:
- アナボリックアンドロゲンステロイドの使用は,心血管疾患のリスクを大幅に増加させる.
- この発見は,AASの摂取に伴う重大な心血管疾患の危険性を強調しています.
- この研究は,AASに関連する心血管リスクに関する認識と予防戦略の必要性を強調しています.
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