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Updated: May 28, 2025

Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy
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ヒストン遺伝子のRNAポリメラーゼIIは,ヒトの癌の結果を予測する

Steven Henikoff1,2, Ye Zheng1, Ronald M Paranal3

  • 1Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Science (New York, N.Y.)
|February 13, 2025
PubMed
まとめ

ゲノム全体のハイパートランスクリプションは,高濃度のRNAポリメラーゼII (RNAPII) によって特徴付けられ,がんでは一般的です. この研究は,腫瘍におけるRNAPIIの上昇を明らかにし,ヒストン遺伝子の超伝記と癌の進行とアヌプロイディを関連付けています.

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