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Updated: May 6, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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非対称性 アスペロンAとBの有機触媒キノンによる総合成 [5 + 2] サイクル添加

Chunlei Qu1, Lu Chen1, Peng Wang1

  • 1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China.

Journal of the American Chemical Society
|February 13, 2025
PubMed
まとめ

研究者は,抗炎症性ポリケチドアスペロンAとBの最初の非対称的全合成を達成しました. 主なステップはディエルス・アルダー反応とオルガノ触媒によるサイクル添加による核構造の構築であった.

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