ヒト脂肪酸合成におけるアシルキャリアタンパク質のシャトルングのスナップショット

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Updated: May 27, 2025

Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening
07:37

Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening

Published on: May 13, 2020

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Kollin Schultz1,2, Pedro Costa-Pinheiro3,4, Lauren Gardner3,5

  • 1Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kollin.schultz@pennmedicine.upenn.edu.

Nature
|February 20, 2025
PubMed
まとめ

研究者は,ダイナミックな脂肪酸合成酵素 (FASN) を冷凍-EMを用いて視覚化し,そのアシルキャリアタンパク質 (ACP) シャトルメカニズムを明らかにした. 重要なインターフェースの変異はFASNの活性を抑制し,新しい治療法への洞察を提供しました.

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