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関連する概念動画

Aging01:26

Aging

34
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
34
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.2K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

10.4K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
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Updated: May 24, 2025

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
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高級科学者の更新禁止はNIHを揺さぶる

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    |March 6, 2025
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    まとめ

    内部研究イニシアチブを大幅に削減するかもしれない. このアピールは,科学的な取り組みとデータ生成能力の将来を保護することを目的としています.

    科学分野:

    • 政策分析
    • 研究管理
    • 科学的資金調達

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    • ある政府機関が 内部研究活動に影響を与える 政策変更に直面しています
    • この政策は,機関の研究プログラムの範囲を大幅に縮小させる可能性があります.

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