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Updated: May 24, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
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Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

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LINE-1のターゲットのリバーストランスクリプションの構造的メカニズム

George E Ghanim1, Hongmiao Hu1, Jerome Boulanger1

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Science (New York, N.Y.)
|March 6, 2025
PubMed
まとめ

ヒトの長間隔元素-1 (LINE-1) レトロトランスポゾンでは,標的型逆転写法 (TPRT) を使用する. CRYO-EM構造はORF2pのダイナミクスとDNAの改造を明らかにし,PCNAのような要因がLINE-1の逆転移を制御する方法を明らかにします.

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