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Updated: May 23, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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エナチオ・リレー・ダブル [2 + 2 + 2] サイクル添加と運動解像度 [2 + 2 + 2] アルキンとニトリルのサイクル添加により,エナチオ・純粋なスピロピリジンへのアクセス

Li-Gang Bai1, Yu-Qing Zheng1, Han-Nan Chen1

  • 1Hubei Research Center of Fundamental Science-Chemistry, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, and College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Journal of the American Chemical Society
|March 11, 2025
PubMed
まとめ

この研究は,ニトリルとアルキンからエナチオピュアスピロピリドンを合成するためのニッケル触媒サイクロアディションを導入する. これらの新しい方法は,高度な合成と触媒化のために高いエナチオ選択性とスケーラビリティを達成します.

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