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Updated: May 22, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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PCSK9は,SNX17媒介によるLDLRのリサイクルを防止することによって,LDLRの分解を促進する

YangYang Guan1, Xiaomin Liu1, Zetian Yang2

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, China. (Y.G., X.L., X.Z., M.L., M.D., Y.W.).

Circulation
|March 12, 2025
PubMed
まとめ

プロプロテインコンバーターゼサブチリシン/ケキシン9 (PCSK9) は,ソートリングネキシン17 (SNX17) の相互作用を阻害することで,LDLRのリサイクルを防ぐ. LDLRのリサイクルの欠陥はPCSK9阻害剤に対する耐性を引き起こす.

キーワード:
薬剤耐性ハイパーリポプロテイン症 II型リポタンパク質,LDL

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