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Updated: May 21, 2025

Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer
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Nrf3媒介のミトコンドリア・スーパーオキシドは,Pitx2を抑制することによって,心筋細胞のアポトーシスを促進し,心臓の機能を低下させる

Qishan Chen1,2, Ancheng Zheng1,2, Xiaolei Xu1

  • 1Department of Cardiology, Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China (Q.C., A.Z., X.X., Z.S., M.Y., S.S., L.W., Y.W., L.Z.).

Circulation
|March 18, 2025
PubMed
まとめ

核因子エリソイド2関連因子3 (Nrf3) は,Pitx2を抑制することによって,ミトコンドリアのROSと心肌細胞のアポトーシスを増加させ,心筋梗塞 (MI) を悪化させる. このNrf3- Pitx2経路を阻害することで,心臓発作の治療に新しい治療戦略が提供される可能性があります.

キーワード:
アポトーシス心筋細胞心筋梗塞反応性酸素種転写因子

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