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Updated: May 21, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

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エナチオセレクティブC-H機能化およびサイクロプロパン化におけるロジウムカルベンの前駆体としてのグルタリミドを用いた多様性合成

William F Tracy1, Jack C Sharland1, Duc Ly1

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

Journal of the American Chemical Society
|March 18, 2025
PubMed
まとめ

新しい方法により,ステレオ化学的に多様なセレブロンE3リガゼ調節薬 (CELMoD) が作られます. ディロジウム触媒はエナチオ選択的機能化を促進し,標的型タンパク質分解薬の発見の選択肢を拡大する.

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Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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