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Updated: Jul 17, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

リガンド誘発のユビキチネーションは,信号モチーフの膜結合を阻害することによって,LAG3の免疫チェックポイント機能を解放する

Yong Jiang1, Anran Dai2, Yuwei Huang3

  • 1School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Cell
|March 18, 2025
PubMed
まとめ

リンパ球活性化遺伝子3 (LAG3) は,リガンド結合時にK48に結合しないポリユビキチン化によって活性化され,その免疫抑制を強化する. このメカニズムは 治療用抗体によって標的となり 癌の免疫療法に 新たな戦略を提示します

キーワード:
Cbl-b についてLAG3 についてTCRシグナリングc-Cblガンに対する免疫療法チェックポイントユビキチネーション

さらに関連する動画

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model09:00

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model

Published on: April 17, 2026

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