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Updated: May 21, 2025

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death
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インスリンmRNAの加速分解による1型糖尿病に対する遺伝的保護

René van Tienhoven1, Denis O'Meally2, Tristan A Scott3

  • 1Department of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands.

Cell
|March 20, 2025
PubMed
まとめ

特定のインスリン遺伝子変異 (INSP) は,エンドプラズマ網膜のストレス中にインスリンmRNAの分解を加速し,ベータ細胞機能と移植結果を改善することによって,タイプ1糖尿病から保護します.

キーワード:
ERのストレスベータ細胞機能欠陥のあるリボソーム製品遺伝的リスク免疫耐性について免疫性についてインスリン遺伝子ネオアンチゲン1 型糖尿病解き放たれたタンパク質反応

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