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Updated: May 16, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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リンパ内皮の分岐鎖アミノ酸カタボリック欠陥は心臓のリンパ整合性を弱め,HFpEFを誘発する

Xiong Guo1, Chong Huang1, Ling Zhang1

  • 1Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China (X.G., C.H., L.Z., G.H., X.C., F.S., T.L., Z.C., C.L., Y.G., W.Y., Y.X., S.W., H.L., Z. Liu, Z. Lin, X.W., Z.W., F.Z., L.T.).

Circulation
|April 1, 2025
PubMed
まとめ

リンパ内皮細胞 (LEC) の欠陥のある分岐鎖アミノ酸 (BCAA) 代謝に関連した心臓リンパ機能障害は,保存されたエジェクション分数 (HFpEF) の心不全に大きく寄与する. BCAAの分解とリンパの整合性を回復することは,HFpEFに対する潜在的な治療方法を提供します.

キーワード:
アミノ酸,分岐鎖内皮細胞心不全リンパ血管新生血管内皮成長因子受容体-3

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