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Neurulation01:30

Neurulation

41.5K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.5K
The Cochlea01:13

The Cochlea

44.4K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.4K
Auditory Pathway01:15

Auditory Pathway

4.5K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
4.5K
Hair Cells01:22

Hair Cells

39.9K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
39.9K
Anatomy of the Ear01:16

Anatomy of the Ear

7.1K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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Updated: May 21, 2025

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
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Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

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エクトダームのバーコードは,神経と頭の区画化を示している.

Sandra de Haan1,2,3, Jingyan He1, Agustin A Corbat1

  • 1Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.

Science (New York, N.Y.)
|April 3, 2025
PubMed
まとめ
この要約は機械生成です。

この研究は,マウスの先端の系統追跡を用いて脊椎動物の発達を追跡しています. 研究者達は 神経頂部とプラコードから 異なる細胞系統を特定し 初期の脳と内耳の組織を明らかにしました

さらに関連する動画

Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation
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Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation

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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

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関連する実験動画

Last Updated: May 21, 2025

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
09:03

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

12.8K
Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation
06:45

Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation

Published on: April 17, 2016

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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

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科学分野:

  • 発達生物学
  • 神経科学
  • 遺伝学

背景:

  • 脊椎動物の発達は プラコードと神経の細胞に依存している.
  • 発達生物学と神経科学にとって 精密な系統と分化を理解することは 極めて重要です

研究 の 目的:

  • ネズミのプラコドとニューラル・クライストの 系統を調べるため
  • 収束した分化経路を明らかにし,異なる細胞系統を識別する.
  • 初期の神経系と内耳の発達について 基礎的な洞察を提供するためです

主な方法:

  • 子宮内ナノ注射 マウスの胚の7. 5日目
  • 遺伝性DNAのバーコードで 血統を追跡する
  • 次世代の単細胞系統の トレーシング
  • クローン分析

主要な成果:

  • ニューラル・クライストとプラコードを含む エクトドームを標的として,効率的な操作を行う.
  • 解明された収束分化経路
  • 神経系,ニューラル・クライスト,オティック・プラコードから派生した系統を特定した.
  • 神経と臓の 早期分断を明らかにした

結論:

  • この研究は,脊椎動物の初期の細胞系統の高解像度マップを提供します.
  • 各種の細胞の祖先細胞関係を特定した.
  • 神経科学と発達生物学の研究のための基礎的な洞察を提供します.