関連する実験動画

Updated: May 22, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
10:27

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta

Published on: December 5, 2019

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アロステリック HECT E3 リガース阻害の治療的可能性

Alexander M K Rothman1, Amir Florentin2, Florence Zink3

  • 1University of Sheffield, Sheffield, UK; Novartis BioMedical Research (NBR), Cambridge, MA, USA.

Cell
|April 3, 2025
PubMed
まとめ

研究者らは,特にSMURF1の謎の穴を標的とした,ユビキチンE3リガゼの新種の阻害剤を発見した. この発見は,BMPR2シグナリングを調節することによって,肺動脈高血圧 (PAH) の新しい治療戦略を提供します.

キーワード:
E6AP についてHECT についてSMURF1 についてアロステリック阻害薬物の発見グリシンヒンジ肺動脈高血圧小分子ユビキチンE3リガゼ血管の改造

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