炎症性および抗炎症性サイトキンは,不安を調節する桃体回路を双方向に調節する

Byeongjun Lee¹, Jeong-Tae Kwon¹, Yire Jeong¹

¹The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell

|April 8, 2025

まとめ

サイトカインは特定の脳ニューロンに作用して不安を調節しますプロ炎症性 (インタールイキン17A/C) と抗炎症性 (インタールイキン10) サイトカインは,基礎側桃体の神経刺激性と行動に影響します.

科学分野:

神経免疫学
行動神経科学
分子精神医学

背景:

バイトキンのような周辺の免疫分子は気分や行動に影響します
サイトカインが脳機能に影響を及ぼす正確な神経回路はほとんど不明です
自己免疫疾患や感染症の炎症エピソードは,持続的な気分変化につながる可能性があります.

研究の目的:

サイトカインが不安に関連した行動を調節する方法を調べるため
脳の特定の神経回路を標的にする
内部状態の調節におけるサイトカインシグナル伝達の役割を明らかにする.

主な方法:

基礎側桃体 (BLA) の神経刺激性に対するサイトカインの効果を調べた.
BLAニューロン機能に対するインタールイキン-17A (IL-17A),インタールイキン-17C (IL-17C),およびインタールイキン-10 (IL-10) の影響を調査した.
インタールイキン17受容体A (IL-17RA) 抗体を利用し,その結果生じた行動変化を評価した.

主要な成果:

サイトカインは神経調節剤として働き,BLAの受容体発現ニューロンを通して不安を調節する.
IL- 17AとIL- 17Cのレベルが上昇すると,BLAニューロンの興奮性が増加し,不安が促進される.
インタールイキン10 (IL-10) は,BLAニューロンの興奮性と行動に逆効果を発揮した.
同じBLAニューロン集団のサイトカイン受容体 (IL-17RA/REとIL-10受容体) がこれらの効果を媒介する.

結論:

サイトカインシグナル伝達は,特定のBLAニューロン集団を通して双方向的に不安を調節します.
炎症性および抗炎症性サイトカインは,内部状態を制御する神経基板に直接影響を及ぼします.
この研究は外周炎症と脳の機能や行動の変化を直接的に結びつけるメカニズムを強調しています

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