関連する実験動画

Updated: May 15, 2025

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy
12:18

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

Published on: December 26, 2014

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筋肉のアセチルコリン受容体構造を通して解明された自己免疫機構

Huanhuan Li1, Minh C Pham2, Jinfeng Teng1

  • 1Department of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|April 9, 2025
PubMed
まとめ

研究者は,ヒトの成人アセチルコリン受容体 (AChR) を冷凍-EMを用いて視覚化し,ミアステニア・グレイビス (MG) の自己抗体がどのように筋肉機能を妨害し,パーソナライズされたMG治療の道を開くことを明らかにしました.

キーワード:
アセチルコリン受容体オートアンチボディ自己免疫疾患クリオ電子顕微鏡電気生理学イオンチャネル筋肉の弱さミアステニア・グレイヴィス構造生物学

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