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Updated: May 15, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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異なるプライミング・フェーズは,パラクリンIL-2信号をオーケストラ化することによってCD8T細胞の免疫を調節する

Katarzyna Jobin1, Deeksha Seetharama1, Lennart Rüttger1

  • 1Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University Würzburg, Würzburg, Germany.

Science (New York, N.Y.)
|April 10, 2025
PubMed
まとめ

活性化されたT細胞は,重要な分化信号のために, dendritic cells (DCs) と再結合する. この相互作用は,特にCD8T細胞では,CXCR3が関与し,ワクチン開発に影響を与えるインタールイキン-2 (IL-2) を供給するCD4T細胞によってサポートされます.

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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity06:16

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